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KMID : 0381219720040080484
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Journal of RIMSK
1972 Volume.4 No. 8 p.484 ~ p.489
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HEARING LOSS DUE TO DRUGS
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Abstract
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All antibiotics with ototoxic effects are thought to be drugs produced by some streptomyces except colistin and gentamicin; they are streptomycin, neomycin, kanamycin, vancomycin and viomycin. In contrast to streptomycin, neomycin etc, deafness in most instances is not progressive for long period after administration of kanamycin is stopped.
Because a high-pitched tinnitus is often the first symptom of impending difficulty, conversational hearing loss may be prevented by omitting the antibiotic agent as soon as the tinnitus is manifest.
For the purpose of the prevention of deafness, alcohol and tobacco should be reduced or forbidden in a person who has deaf family; and the opinion that the toxicity of salicylate and quinine is underestimated by both the laity and physicians should be avoided.
New, toxic hearing loss due to heavy metals may be prevented, too, by increasing industrial hygienic measures and preventing accident ingestions.
Audiometric determinations should be carried out before ototoxic drug therapy is initiated, and repeated at frequent intervals during the period of treatment.
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